Cosmetic powder Nmn β-nicotinamide mononucleotide anti-aging 1094-61-7

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Cosmetic Powder Nmn Beta-Nicotinamide Mononucleotide for Anti Aging 1094-61-7
                                         Product Description                                                  


 
Product NameNMN / Nicotinamide mononucleotide
Appearance White powder
Purity99%
Molecular Weight334.22
CAS No1094-61-7
Molecular FormulaC11H15N2O8P
 
Nicotinamide mononucleotides play an important role in the production of human cell energy, which is involved in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion).


Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic  sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. It is to be used for research only.


                                           Applications                                                              

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.

NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. However, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.


Cosmetic Powder Nmn Beta-Nicotinamide Mononucleotide for Anti Aging 1094-61-7




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Cosmetic Powder Nmn Beta-Nicotinamide Mononucleotide for Anti Aging 1094-61-7

 

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Cosmetic Powder Nmn Beta-Nicotinamide Mononucleotide for Anti Aging 1094-61-7

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                                       Company Information                                                 

XI'AN Tian Guangyuan Biotech Co.,Ltd.was founded in May 2003, is a professional animal and plant extracts modern and advanced enterprise object, chemical intermediates and active ingredients of natural active throughout the country, plant extracts industry, research and development, production, marketing and other areas have a strong strength.

The company is headquartered in the outskirts of Xi'an, under research and development center as well as analysis and testing center, comprehensive strength in the national forefront of the industry.
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Cosmetic Powder Nmn Beta-Nicotinamide Mononucleotide for Anti Aging 1094-61-7

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